Be amazing! Understand your hormones Pregnenolone


Our hormones effect everything we do. They effect how we feel, look, think, age, our skins, our muscles, our hair, our sleep and how well we function though out the day.

Over the next few issues, I am going to look at each and every hormone and how it effects us. Some of these hormones we can actually take as supplements to turn back the clock and improve out happiness factor!


The memory and happy hormone!

Ok – say Pregnenolone three times quickly!

But seriously…………

Pregnelone is the precursor to every other hormone. It is the ‘mother’ of all steroid hormones including DHEA, progesterone, testosterone, estrogen and cortisol.

It is synthesised from cholesterol. It is mainly developed in the adrenal glands, but also in the liver, skin, brain, testicles, ovaries and retina of the eyes, nervous tissue, and in the bloodstream.

It stimulates our memory storage process. When we have enough Pregnenolone in our systems, we feel happy, healthy and do not suffer from stress.

Unfortunately this hormone decreases as we age, by 75 we produce 60% less than we do in our mid thirties. For women, this hormone drops dramatically during our menopausal years, which is why so many women suffer from depression and mental confusion when they become Perimenopausal and onwards. Personally I know now when I am low, as I become confused and disorientated and cannot cope with any form of stress. Ongoing stress will decrease our pregnenolone levels, and speeds up the ageing side effects as it can not replace itself.

As Pregnenolone decreases, so do all of our other hormones as it is the raw material from which all other steroid hormones are made.

What this means is that we start to experience  physical and mental decline. Loss of energy, memory loss and sexual decline, hearing impairment, arthritis and cardiovascular disease are just some of the symptoms.

Sleep and Memory.

Pregnenolone has powerful memory-enhancing effects, far beyond that of other neuroactive substances. In healthy men aged 20 to 30, administration of pregnenolone (1 mg daily) was found to improve sleep quality and decrease intermittent wakefulness. Pregnenolone has also been shown to affect working, short-term and long-term memory, and may result in increased motivation to learn new information, and an improvement in the ability to acquire new knowledge.


Pregnenolone plays a role in the neuroendocrine response to stress. In a study of airplane pilots subjected to stress, administration of pregnenolone (25 mg twice daily) improved performance without causing adverse side effects.

Hormones are known to affect mood and behaviour by the way they affect the nervous system. In people with either current depression or a history of depression, pregnenolone in the cerebrospinal fluid (the fluid that bathes the brain) was significantly lower than levels in healthy people. In addition, it was found that patients with active depression had lower levels of pregnenolone compared with those with a prior history of depression.


Researchers have reported on the use of pregnenolone in a variety of rheumatologic diseases. In a study of pregnenolone therapy for rheumatoid arthritis, six of eleven people experienced moderate to marked improvement in symptoms of joint pain and joint mobility. Improvement was noticed two to four days after therapy was initiated. In a study of 13 adults with osteoarthritis, pregnenolone therapy reduced the pain and improved the range of motion in seven of the study participants. Pain recurred when therapy was discontinued. In a person who suffered from gouty arthritis that was unresponsive to conventional medications, pregnenolone therapy resulted in a dramatic response within three days of initiating therapy. This patient received 300mg daily of pregnenolone for four weeks, followed by 200mg weekly of pregnenolone as a maintenance amount. This study of pregnenolone therapy in rheumatologic diseases also reports a substantial benefit in patients with systemic lupus erythematosus (SLE), psoriasis, and scleroderma. No systemic adverse effects were reported.


Perimenopausal and Menopausal women loose different levels of hormones, be it DHEA, estrogen, progesterone or testosterone. Pregnenolone will fill in the gaps – replacing which ever hormone needs replacing. Depending on who you read, depends on how much you are recommended to take as a supplement. 50 mg per day, works for me. As long as I sleep, and exercise, I suffer with no hot flushes and my memory is great, as well as my happiness factor!

Are there any side effects?

• Pregnenolone is an appropriate supplement for men and women of all ages.
• Pregnenolone has an impressive record with very low levels of toxicity and is safe for    human use.
• Do not use pregnenolone if you are supplementing DHEA.
• Do not use if you suffer from seizure disorders, as pregnenolone can suppress GABA activity, resulting in an increase in central nervous system activity which may lead to seizures in those with epilepsy.

Where can I get it?

My favourite supplier, and where most of the above information is from is Biovea

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